This course aims to assist you in cultivating a systematic and structured approach to problem-solving and method development. Through the acquisition of this approach, you will be able to reduce the time and expenses associated with developing and validating methods for capillary gas chromatography (GC) and high-performance liquid chromatography (HPLC). Additionally, you will enhance the effectiveness and quality of your method troubleshooting and the chromatographic data you generate.

Course Objectives:

How to develop a systematic, structured approach to problem solving and method

Specifics of a step-by-step process for method validation and for building quality assurance into chromatographic methods
Case studies using practical examples, developed in small groups
Method diagnostics, troubleshooting, and preventive maintenance
The interdependence of methods, sample preparation, instrumentation, columns, detectors, and quantitation
Implementing good laboratory practices (GLP)
Sample preparation techniques
Methods development based on the chemistry and chemical properties of the sample analytes and matrice

Who Should Attend?

Laboratory managers, supervisors, chemists, and technicians working in methods development, R&D, manufacturing/process testing, testing services labs, teaching, QA/QC, analysis, or product testing/development. Chemists, biologists, and engineers involved in organic chemicals, petroleum/petrochemicals, fine chemicals, polymers, environmental, pharmaceutical, forensic sciences, molecular/cellular biology, protein chemistry, foods/flavors/fragrances, occupational health and/or product/process safety testing will benefit.

Course Outlines:

Discuss your method development and analytical problems with acclaimed instructors who have more than 60 years of combined experience in industry, government, and academe
Learn how to develop rugged GC or HPLC methods in a timely, cost-effective, systematic manner
Learn how to develop a preliminary chromatographic method in less than one day
Solve real chromatographic analysis problems during the course, using small working groups, the instructors, and the method development tools from the course
Understand how to systematically troubleshoot GC or HPLC methods in a cost-effective manner
Learn the applications and limitations of, and how to use more than 100 chromatographic and sample preparation techniques to develop new, modified, and/or validated methods
Learn how to build method validation and QA into chromatographic methods
Learn how to use simplified method development tools to select the best techniques the first time through the method development process
Learn to recognize good results from poor results and how to improve performance
Course Schedule
The Method Development Process for GC and HPLC
Method Development Parameters, Based on the Sample Matrix and Analytes
Method Validation
Preventative Maintenance and Troubleshooting
Case Studies with Real Analytical Method Problems

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