Gas Chromatography/Mass Spectrometry (GC/MS): Technology, Problem Solving and Latest Practice
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Gas Chromatography/Mass Spectrometry (GC/MS): Technology, Problem Solving and Latest Practice Course
Introduction:
This comprehensive five-day course focuses on mass spectrometry, encompassing both LC/MS and GC/MS. The lecture segment provides a foundational understanding of mass spectrometry principles, including the interpretation of mass spectra. Practical guidance on operating and maintaining mass spectrometers is also covered.
In collaboration with leading Mass Spec vendors, the laboratory component of the course offers students a unique opportunity to gain hands-on experience with cutting-edge instrumentation. These are not pre-scripted demonstrations but rather authentic, real-world exercises that reinforce the fundamental concepts taught in the lectures.
To foster collaborative learning, students are assigned to small groups consisting of three to four individuals. Throughout the week, they work together to solve homework problems, analyze experimental data, and prepare presentations. This group dynamic promotes knowledge sharing and teamwork, enhancing the overall learning experience of the participants.
Course Objectives:
You Will Learn A Theoretical and Practical Knowledge of:
- Operating Principles of LC/MS and GC/MS
- Strategies for Data Interpretation – EI, CI, MS/MS, and In-Source CAD
- Ionization Techniques – EI, CI, APCI, APPI, ES, and other techniques
- Inlet-System Interfacing for LC and GC
- Quantitation Using GC/MS and LC/MS
- Instrument Maintenance
- Experimental Design
- Use of computer tools for generating and dealing with LC/MS, GC/MS, and MS/MS data
- Optimization of GC/MS and LC/MS Methods
- MS Requirements for Hyphenated Techniques
- The best modern reference materials for the mass spectrometrist
Who Should Attend?
This course is offering everything the professional and the novice needs to know about running, maintaining, and interpreting the results from Gas Chromatography. Analytical chemists, technicians, and scientists in allied disciplines will regard this course as the best in gas chromatography. In addition to serving as an invaluable update for the experienced practitioner, this course provides the beginner with a solid understanding of gas chromatographic theory and basic techniques.
Course Outlines:
Laboratory Sessions Offer Top-Quality Training and Individual Attention:
The laboratory sessions include computer analysis of data that you have acquired using various GC/ and LC/MS systems. Small groups of three or four participants and an expert coach will be given a specific problem and acquire the data necessary to solve the problem. You and your group will then make a presentation on your results and conclusions.
Experiments and Exercises Provide Valuable Hands-On Experience in GC/MS and LC/MS
Laboratory exercises involve data acquired in electron ionization and chemical ionization (EI and CI) for GC/MS and electrospray ionization and atmospheric pressure chemical ionization (ESI and APCI) for LC/MS as well as data acquired in MS/MS. The course deals with chromatographic analytes with a molecular mass to about 1,000 Da. The laboratory sessions challenge your problem-solving skills using data that you acquire on the latest modern instruments supplied to this course by our supporting instrument manufacturers.
Other Key Ways You’ll Benefit from Attending this Course:
- Consult with expert instructors about your analytical problems and challenges.
- Develop a strategy for interpreting mass spectral data.
- Learn which compounds are amenable to which mass spectral techniques.
- Learn the operating principles of ionization sources, m/z analyzers, and detectors.
- Learn the operating principles of sample inlet systems (direct-probe and GC and LC inlets) and associated vacuum systems.
- Learn how to process data with a data system; appreciate various aspects of tuning and troubleshooting a mass spectrometer.
- Obtain experience in the library searching on benchtop data systems and the use of other computer-aided mass spectral interpretation tools.
- Use a vast array of the latest in modern GC/MS and LC/MS instrumentation.
- Become familiar with the complexity and care involved in operating the mass spectrometer with a separation technique.
- Learn the techniques of accessing literature on mass spectrometry research and application