Toxicology for non-Toxicologists Training
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Toxicology for non-Toxicologists Training Course
Introduction:
Course Objectives:
You Will Learn:
· What factors determine the impact toxic substances have on the body?
· How metabolism affects toxicity
· Various types of carcinogens and how they react within the body
· Which genetic disorders can result from exposure to toxic chemicals
· Which chemicals cause respiratory abnormalities?
· Which exposure pathways are most likely to result in chronic intake?
· Approaches and strategies for Risk-Based Corrective Action
Who Should Attend?
- Beginning industrial hygienists
- Occupational safety practitioners
- Environmental health practitioners
- Safety professionals
- Nurses
- Plant managers
- Supervisory personnel
- Union representatives
- Personnel managers
- Research chemists
- Physicians
Course Outlines:
Understanding the General Principles of Toxicology:
This opening session will lay the basic framework upon which the remainder of the course is built. It will begin by answering the fundamental questions: What exactly is toxicology? Upon what sciences is it based? Then the course will move into the terminology and key definitions you’ll need to know, as well as the key principles you’ll need to understand.
Understanding the General Principles of Toxicology:
You’ll learn what factors determine the impact toxins have on the body and the dose-response relationship. Discover how the absorption, distribution, metabolism, and excretion of chemicals affect toxicity (toxic kinetics).
Reproductive Toxicity and Carcinogenesis
Examine the effects toxic substances can have on the reproductive process and the likelihood of their causing cancer. Learn what defects and abnormalities are likely to occur during various stages of fetal and embryonic development. Learn what genetic disorders can occur.
Discuss the various types of carcinogens, how they react within the body to form cancers, and how the resulting hazards are categorized.
How Chemicals Impact the Liver, Kidneys, Blood, and Immune System
Serious consequences occur as a result of exposure to toxic chemicals.
Damage to the liver, kidneys, blood, and immune system is common.
Review the functions of these organs and systems and find out what effects toxins have on them. You will also learn what tests are used to assess the extent of damage caused by the chemicals.
How Chemicals Impact the Skin, Lungs, Eyes, and Nervous System
Review the important functions of the skin, lungs, eyes, and nervous system and learn the responses that occur when they are exposed to toxins. What chemicals cause respiratory abnormalities? What chemicals are known neurotoxicants? What substances cause toxic responses in the eyes?
Review of Toxicity of Selected Chemicals
You’ll focus on the toxicity of several widely distributed chemicals including dioxins, metals, and chlorinated hydrocarbons. Discuss, in layperson’s terms, the latest scientific findings on dose and response profiles.
Role of Toxicology in Risk Assessment
Risk assessments are crucial tools in identifying how a chemical release will impact human health or the environment. Look at how toxicity information is used in determining these risks. Find out what agencies and key legislation are driving risk assessment. Learn the various types of risk assessment, the exposure pathways most likely to result in chronic intake, how you can use risk assessments to determine appropriate exposures within facilities and cleanup standards for contaminated sites.
Risk-Based Corrective Action
You’ll learn new approaches for Risk-Based Corrective Action, including applications of the ASTM model for petroleum release sites and new ASTM standards for non-petroleum release sites. You’ll also discuss extensions of these models to other sites.